My Titleist T200 irons have a 43 PW and 48 GW, so 5 degrees there. I also play a 54 and 60 SM8. I do not notice any issues, but approach shots are not my strength. The 54 was the result of only being able to find that wedge grind and bounce in the 54. I think we are all faced with partial approach shots, some more than others. Learning your wedge set distances may be more important than the specific degree gaps.